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New Approaches to Cancer Therapy for the 21st century

“A new scientific truth does not triumph by convincing its opponents, but rather because its opponents die, and a new generation grows up that Is familiar with it.”

Biological therapy uses your immune system to fight cancer.

Human cancer comprises more than 200 different diseases. Together, they account for about one fifth of all deaths in the industrialized countries of the Western World. One person out of three will be treated for a severe cancer in their life-time. Since the incidence of most cancers increases with age, these figures are going to rise, if life expectancy continues to increase.

Four carcinomas are particularly important with regard to incidence as well as mortality. Cancers of the lung, colon and rectum are the most significant problems in both genders, together with breast cancer in women and prostate cancer in men.

What options exist for cancer to be treated successfully?

The number of therapeutic options available for the treatment of malignancies has increased rapidly in recent years with the introduction of immunotherapies and biological therapies, as well as novel cytotoxic and targeted chemotherapeutic agents.3 However, the majority of cancer patients who undergo conventional orthodox cancer treatments are under remission but have the risk of a relapse due to Minimal Residual Disease. End-stage disease patients are left hopeless because their cancer has developed resistance to conventional orthodox treatments.

The Potential to Advance Modern Medicine for Cancer patients

The combination of Extracorporeal Photopheresis (ECP) with dendritic cells vaccine (DCs) has substantial potential for the management of life-threatening or debilitating antigenic cancers and T-cell mediated disorders. This method is an improvement over the FDA-approved treatment for cutaneous T-cell lymphoma due to research by Richard L. Edelson, Yale University.

The Ultraviolet A irradiation device accomplishes two important purposes; it activates the 8-MOP molecules inducing apoptosis and it activates monocytes efficiently inducing their conversion into Dendritic antigen presenting cells, the cells which initiate immune reactions. The combination of 8-Metoxipsoralen orally and ultraviolet A irradiation causes the majority of treated cells to undergo apoptosis within 24 hours of the photopheresis procedure. The malignant cells are gently but irreversible damaged, initiating the apoptosis which begins to become evident overnight following the treatment over the next day, the monocytes enter the Dendritic cell pathway, becoming immature DC’s which efficiently internalize the apoptotic malignant cells, processing and presenting the derived tumor antigens to responding antitumor T cells.

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Dr. Raúl Morales Aceves